一、基本信息

杨云云，博士，副教授，硕士生导师

电子邮件：yang_yy(at)hubu.edu.cn

研究方向：主要结合结构生物学、生物化学等手段研究：（1）重要工业酶的结构和催化机制；（2）疾病相关重要蛋白质的结构和分子机制；（3）生成抗肿瘤天然产物过程中的酶促反应机制。已在Cell、Immunity、Angew Chem Int Ed、ACS Catalysis等SCI期刊发表15篇高水平文章，其中以第一作者（包含共同第一）在Immunity、Angew Chem Int Ed、ACS Catalysis（两篇）等高水平SCI期刊上发表文章6篇，2篇获选为封面文章，申请国内外专利4项。

二、教育背景

2016–2019  清华大学，博士

2012–2015  天津科技大学和中科院天津工生所，联合培养硕士

2008–2012  青岛农业大学海都学院，学士

三、工作经历

2021至今    湖北大学，副教授

2020–2021  湖北大学，博士后

2015–2016  清华大学，科研助理

四、主持科研项目

1. 国家自然科学基金面上项目，50万，主持

2. 国家重点专项青年项目，2021.12−2026.11，100万，项目骨干

3. 国家自然科学基金青年项目，2022.01−2024.01，30万，主持

4. 湖北省人才项目，30万，主持

5. 中国博士后特别资助，2021.03−2022.01，18万，主持

6. 中国博士后面上项目，2020.04−2022.01，8万，主持

7. 湖北省博士后创新研究岗位，2020.04−2022.01，6万，主持

五、代表性论文（#共同一作，*通讯作者）

1. Yuan, L.^#, Ma, X.^#, Yang, Y.^#, Qu, Y., Li, X., Zhu, X., Ma, W., Duan, J., Xue, J., Yang, H., Huang, J.-W., Yi, S., Zhang, M., Cai, N., Zhang, L., Ding, Q., Lai, K., Liu, C., Zhang, L., Liu, X., Yao, Y., Zhou, S., Li, X., Shen, P., Chang, Q., Malwal, S. R., H, Y., Li, W., Chen, C., Chen, C.-C., Oldfield, E., Guo, R.-T.^*, Zhang, Y.^*, (2023) Phosphoantigens glue butyrophilin 3A1 and 2A1 to activate Vγ9Vδ2 T cells. Nature 621, 840–848 (IF=64).

2. Yang, Y.^#, Li, L.^#, Yuan, L.^#, Zhou, X.^#, Duan, J., Xiao, H., Cai, N., Han, S., Ma, X., Liu, W., Chen, C. C., Wang, L., Li, X., Chen, J., Kang, N., Chen, J., Shen, Z., Malwal, S. R., Liu, W., Shi, Y., Oldfield, E.*, Guo, R. T.*, Zhang, Y.* (2019). A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated Vγ9Vδ2 T Cell Activation. Immunity 50, 1043-1053. (IF=31.745)

3. Chen, C. C.^#, Hu, X.^#, Tang, X.^#, Yang, Y.^#, Ko, T. P., Gao, J., Zheng, Y., Huang, J. W., Yu, Z., Li, L., Han, S., Cai, N., Zhang, Y.*, Liu, W.*, Guo, R. T.* (2018). The Crystal Structure of a Class of Cyclases that Catalyze the Cope Rearrangement. Angewandte Chemie International Edition 57, 15060-15064.  (IF=15.336)

4. Malwal, S. R.^#, Gao, J.^#, Hu, X.^#, Yang, Y.^#, Liu, W., Huang J. W., Ko, T. P., Li, L., Chen, C. C., O’Dowd, B., Khade, R. L., Zhang, Y., Zhang, Y.*, Oldfield, E.*, Guo, R. T.* (2018). Catalytic Role of Conserved Asparagine, Glutamine, Serine, and Tyrosine Residues in Isoprenoid Biosynthesis Enzymes. ACS Catalysis 8, 4299-4312. (IF=13.084)

5. Zeng, W.^#, Li, X.^#, Yang, Y.^#, Min, J.^#, Huang J. W., Liu, W., Niu, D., Yang, X., Han, X., Zhang, L., Dai, L., Chen, C. C.*, Guo, R. T.* (2022).Substrate-Binding Mode of a Thermophilic PET Hydrolase and Engineering the Enzyme to Enhance the Hydrolytic Efficacy. ACS Catalysis 12, 3033-3040. (IF=13.084)

6. Yang, Y.^#, Ko, T. P.^#, Chen, C. C.^#, Huang, G., Zheng, Y., Liu, W., Wang, I., Ho, M., Hsu, S., O'Dowd, B., Huff, H., Huang, C. H., Docampo, R., Oldfield, E.*, Guo, R. T.* (2016). Structures of Trypanosome Vacuolar Soluble Pyrophosphatases: Antiparasitic Drug Targets. ACS Chemical Biology 11, 1362−1371.

7. Wang, J.^#, Chen, C. C.^#, Yang, Y.^#, Liu, W., Ko, T. P., Shang, N., Hu, X., Xie, Y., Huang, J. W., Zhang, Y.*, Guo, R. T.* (2018). Structural Insight into a Novel Indole Prenyltransferase in Hapalindole-type Alkaloid Biosynthesis. Biochemical and Biophysical Research Communications 495, 1782-1788.

8. Xia, Y.^#, Xie, Y.^#, Yu, Z.^#, Xiao, H., Jiang, G., Zhou, X., Yang, Y., Li, X., Zhao, M., Li, L., Zheng, M., Han, S., Zong, Z., Meng, X., Deng, H., Ye, H., Fa, Y., Wu, H., Oldfield, E., Hu, X., Liu, W.*, Shi, Y* and Zhang, Y.*. (2018). The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery. Cell 175, 1059-1073. (IF=38.637)

9. Tang, X.^#, Xue, J.^#, Yang, Y., Ko, T. P., Chen, C., Dai, L., Guo, R. T., Zhang, Y.* and Chen, C. C.*. (2019). Structural Insights into the Calcium Dependence of Stig Cyclases. RSC Advances 9, 13182-13185.

10. Gao, J.^#, Ko, T. P.^#, Chen, L.^#, Malwal, S. R.^#, Zhang, J., Hu, X., Qu, F., Liu, W., Huang, J. W., Cheng, Y. S., Chen, C. C., Yang, Y., Zhang, Y., Oldfield, E., and Guo, R. T.*. (2018). "Head-to-Middle" and "Head-to-Tail" cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase. Angewandte Chemie International Edition 57, 683-687. ( IF=12.959)

11. Zheng, Y.^#, Ko, T. P.^#, Yang, Y., Shao, W.*, Guo, R. T.*. (2015). Binding Mode of the Oxidized a-anomer of NAD+ to RSP, a Rex-family Repressor. Biochemical and Biophysical Research Communications 456, 733-736.

12. Zheng, Y., Chen, C. C., Ko, T. P., Xiao, X., Yang, Y., Huang, C. H., Qian, G., Shao, W.*, Guo, R. T.*. (2015). Crystal Structures of S-adenosylhomocysteine Hydrolase from the Thermophilic Bacterium Thermotoga Maritima. Journal of Structural Biology 190, 135-142.

13. Peng, W.^#, Ko, T. P.^#, Yang, Y., Zheng, Y., Chen, C. C., Zhen Zhu, Huang, C., Zeng, Y., Huang, J. W., Wang, Andrew H.-J., Liu, J.-R.*, and Guo, R. T.*. (2014). Crystal structure and substrate-binding mode of the mycoestrogen-detoxifying lactonase ZHD from Clonostachys rosea. RSC Advances 9, 13182-13185.

六、获奖与荣誉称号

1. 2020年获得“清华大学优秀博士毕业生”

2. 2020年获得“清华大学优秀博士学位论文”

3. 2020年获得“启航奖”

4. 2019年获得“国家奖学金”

5. 2019年获得“卓越奖学金”

6. 2018年获得“光华奖学金”